Summary
The Ford E150 has 7 recalls spanning 1992 to 2013, with the most serious recent issue being a tire tread belt separation on 2010 models where Michelin LTX LT225/75R16 tires can lose their tread or deflate rapidly, causing the driver to lose control.
The 2006-2013 model years cover two separate issues. On 2006-2013 vehicles modified by Mobility Works with Ricon wheelchair lifts, the lift platform side plate can crack, allowing the platform to separate and rest against the lift door opening. On 2006 models with a 5.4L engine, the fuel rail cross-over hose can develop a fuel leak over time, and fuel near an ignition source can result in a fire.
Going back further, 1999 models with "60/40" hinged side cargo doors have a door latch striker that can develop stress cracks, meaning the door may not hold properly under load. The 1997 model year has a specific issue limited to vehicles with an ambulance prep package and a mid-ship fuel tank: rough road use can cause the tank to crack where it contacts the frame, leaking fuel.
The 1992 model year has two issues. The speed control deactivation switch can overheat and ignite a fire in the engine compartment, whether the vehicle is running or parked. There is also a compliance label issue where the tire placard on 1992 vehicles incorrectly identifies standard-load P235/75R15 tires as appropriate for the vehicle rather than the required extra-load rating, which could lead to underloading the tires for the vehicle's weight.