The 2007 Mercedes-Benz E350 has 5 recalls, the most significant being a sunroof glass panel that can detach from the vehicle while driving and become a road hazard for other traffic.
The sunroof concern covers multiple filing periods, with the core issue being that the bond between the glass panel and the sliding roof frame can deteriorate until the panel separates entirely. Prior repair attempts did not fully resolve the issue, which is why multiple recall campaigns address the same defect. There is also a separate concern limited to E350 4Matic Wagon models: a connecting rod in the load-leveling rear suspension can fail, reducing the driver's ability to control the vehicle.