The 2016 Isuzu NPR HD has 7 recalls, the most serious involving a rear wheel hub that can work loose from the axle and cause a loss of vehicle control and reduced braking, a stuck accelerator pedal that can make the truck difficult to slow or stop, and loose rear axle U-bolt nuts that can allow the propeller shaft to separate and stall the vehicle.
On the structural side, broken transmission mounting studs can leave the transmission unsupported, causing it to shift incorrectly and raising the risk of a crash. Two recalls cover the onboard fire extinguisher, which may fail to discharge properly in a fire. There is also a label recall affecting trucks with the 5.2L diesel engine, where a tire placard with incorrect or unreadable rim size, tire pressure, and weight information can lead to overloading or underinflation.