The 2017 Isuzu NPR XD has 4 recalls, the most serious involving the rear axle: loose wheel hub bolts can let the left rear wheel shift outward, reducing braking performance and vehicle control, and separately, loose U-bolt nuts can allow the rear axle to misalign until the driveshaft separates, cutting power to the rear wheels and stalling the truck.
On the structural side, the frame crossmember that supports the transmission may have metal burrs left over from manufacturing that can crack or break the transmission mounting studs over time. Once those studs fail, the transmission loses proper support and may not shift correctly, leaving the driver unable to select gears normally. There is also an equipment concern: the onboard fire extinguisher may not function properly when needed, leaving no reliable way to suppress a fire if one breaks out in or around the vehicle.